Revolution Plus represents an advancement in feline parasite prevention, combining two powerful active ingredients—selamectin and sarolaner—to provide comprehensive protection against a wide range of internal and external parasites. This innovative topical medication addresses a significant gap in feline parasite control by adding robust tick protection to the already extensive coverage provided by the original Revolution formulation. Since its FDA approval for veterinary use, Revolution Plus has become a preferred choice for veterinarians seeking to provide their feline patients with the most complete single-product parasite prevention available. The combination formulation is particularly valuable for cats living in areas where tick-borne diseases are prevalent or for those with outdoor access who face exposure to multiple parasite types.
The dual mechanism of action in Revolution Plus allows it to target parasites through two distinct pathways. Selamectin, a macrocyclic lactone, works by binding to glutamate-gated chloride channels in invertebrate nerve and muscle cells, causing paralysis and death of susceptible parasites including fleas, heartworm larvae, ear mites, and certain intestinal worms. Sarolaner, an isoxazoline compound, targets gamma-aminobutyric acid and glutamate-gated chloride channels in arthropods, providing potent activity against ticks and additional flea-killing efficacy. This complementary approach ensures that parasites are attacked through multiple mechanisms, enhancing overall effectiveness and providing rapid parasite knockdown. Once applied topically, both ingredients are absorbed systemically, distributing throughout the body to provide comprehensive protection.
Revolution Plus is available exclusively as a topical spot-on solution in single-dose applicator tubes, color-coded by weight range for cats and kittens eight weeks of age and older weighing at least 2.8 pounds. The product is applied once monthly to the skin at the base of the neck, where it is absorbed and distributed systemically. Application is quick and convenient, typically requiring less than a minute, making it an attractive option for cat owners compared to multiple single-purpose products or oral medications. The formulation dries quickly after application, minimizing the potential for transfer to other pets or household surfaces. Most cats accept the application well, though some may experience temporary behavioral changes immediately after application due to the sensation of the liquid on their skin.
The safety profile of Revolution Plus in cats is well-established through extensive clinical trials and post-market surveillance. The product has been shown to be safe for kittens as young as eight weeks, for breeding cats, and for cats in various health states when used according to label directions. The addition of sarolaner to the formulation has not significantly increased the adverse effect profile compared to selamectin alone, though owners should remain vigilant for any unusual reactions. Veterinary supervision is essential when initiating any parasite prevention program, and accurate dosing based on current body weight helps ensure both efficacy and safety. Regular monthly application throughout the year provides optimal protection against the spectrum of parasites that Revolution Plus targets.
