Health

Hip dysplasia, Collie eye anomaly (CEA), and epilepsy are considered the primary genetic diseases of concern in the breed at this time. Collie eye anomaly (CEA) is a congenital, inherited eye disease affecting Border Collies and other breeds involving the retina, choroid, and sclera. In Border Collies, it is generally a mild disease and rarely significantly impairs vision. There is now a DNA test available for CEA and, through its use, breeders can ensure that they will not produce affected pups. There are no genetic tests available for hip dysplasia or epilepsy, although careful breeding practices are known to lower the incidence of both.

Elbow dysplasia or Osteochondritis, deafness, and hypothyroidism may also occur in the breed. Dogs homozygous for the merle gene are likely to have eye and/or hearing problems. Responsible breeders do not mate merles to one another.

Neuronal ceroid lipofuscinosis (NCL) is a rare but serious disease. NCL results in severe neurological impairment and early death; afflicted dogs rarely survive beyond two years of age. The mutation causing the form of the disease found in Border Collies was identified by Scott Melville in the laboratory of Dr. Alan Wilton of the School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, Australia. There is no treatment or cure, but a DNA test is now available to detect carriers as well as affected dogs.

Trapped Neutrophil Syndrome (TNS) is a hereditary disease which inhibits the release of neutrophils produced in the bone marrow into the blood stream. Puppies affected with this disease will eventually succumb to infection. Because this is an autoimmune-deficiency disease the puppies present a variety of symptoms depending upon what infections they fall susceptible to, and so it has gone undiagnosed in the past. Once thought to be rare, it is now believed to be responsible for many cases of "fading puppies". There is no cure, but a DNA test is now available to detect carriers as well as affected dogs. Please visit the American Border Collie Association for more information.

Health

Dogs, both pedigree and cross breeds, can be affected with genetic problems. Those known to sometimes occur in English Setters can include congenital deafness, which was reported as affecting 12.4 percent of the 701 English Setters tested by the Louisiana State University in 2010. As at 2013, there has not been any detailed research on this condition undertaken in the UK; autoimmune thyroiditis, which was shown to affect 26.2 percent of 747 English Setters examined between January 1974 until December 2012 in an Orthopedic Foundation for Animals listing; canine hypothyroidism; elbow dysplasia; and allergies, which can include some sensitivity to certain food ingredients and also skin conditions, are known to occur.

In 2004, the U.K. Kennel Club established the Accredited Breeders Scheme, which was later called the Assured Breeders Scheme (ABS). The scheme received UKAS accreditation in April 2013. ABS members are required to adhere to additional criteria than those necessary for basic KC registration. Among the extra requirements is "Ensuring that the parents of each litter are readily identifiable by either Microchip, Tattoo or DNA profile." As of March 2013, breeders of English Setters who are members of the ABS must screen for hip dysplasia.

Some members of the breed may be affected by cancer and this was identified as the most common cause of death of English Setters in a survey undertaken by the Kennel Club; the age of death from this disease was mainly after reaching ten years of age. However, the survey had only received a small response rate. Life expectancy is between 11 and 12 years, though 13 to 15 years is not uncommon.