African fat-tailed geckos are strict insectivores. Unlike omnivorous reptiles, they derive all of their nutrition from whole live prey, which means there is no pelleted or formulated 'gecko food' that can serve as a complete diet. The quality of what you feed is therefore entirely a function of the quality of the insects you offer and how those insects are prepared before they reach the enclosure.
The single most important nutritional concept for this species is the calcium-to-phosphorus ratio. Feeder insects are naturally phosphorus-heavy and calcium-poor, which over time can drive metabolic bone disease if left uncorrected. A healthy diet aims for a roughly 2:1 calcium-to-phosphorus balance in the gecko's overall intake, achieved through a combination of gut-loading the insects and dusting them with calcium powder.
Fat-tailed geckos store energy reserves in their characteristic thick tail, and a well-fed animal carries a tail nearly as wide as its body. The tail is a useful, at-a-glance condition gauge: a thin or pencil-shaped tail signals underfeeding, illness, or parasite load, while an unusually swollen abdomen alongside lethargy can indicate overfeeding or impaction. Because they are nocturnal, feeding is best timed for the evening when the animal is naturally active and its digestive system is primed by belly heat.
Hydration is part of nutrition for this species. They obtain a portion of their water from prey, but a shallow dish of fresh water should always be available, and the humid hide that supports shedding also gives the animal a reliable place to take in moisture.