ReVive (Two Little Fishies) for Invertebrates

Quick Facts

💊 Generic Name
ReVive Coral Cleaner
🏷️ Brand Names
ReVive (Two Little Fishies)
📂 Category
Coral & Anemone Specific
📁 Subcategory
Coral Dips & Treatments
🔬 Drug Class
Coral Dip/Cleaner
🎯 Primary Use
Removal of hitchhiker pests, parasites, and unwanted organisms from coral specimens
💉 Formulations
Liquid concentrate
📋 Administration
Coral dip bath
📝 Prescription Required
No - Available at pet/aquarium stores
✅ Fda Approved
Not FDA approved for invertebrates

ReVive (Two Little Fishies) Overview

ReVive Coral Cleaner, manufactured by Two Little Fishies, stands as one of the most respected and widely used coral dip products in the marine aquarium industry. Developed by renowned marine biologist Julian Sprung, this formulation has earned its reputation through years of effective performance in quarantine protocols worldwide. The product represents a purpose-designed solution for removing unwanted hitchhikers, pests, and parasites from coral specimens, addressing a critical need in responsible reef keeping practices. Two Little Fishies has built their brand on scientific credibility and practical effectiveness, and ReVive exemplifies this approach.

The formulation of ReVive utilizes natural botanical extracts combined with proprietary cleaning agents that work synergistically to dislodge and eliminate pest organisms without harming coral tissue. Unlike harsh chemical treatments that may stress corals significantly, ReVive's approach emphasizes coral-safe pest removal through mechanical and physiological mechanisms. The active components irritate pest organisms and interfere with their attachment mechanisms, causing them to release from coral surfaces where they can be physically removed or left to expire. This mode of action distinguishes ReVive from iodine-based and oxidizer-based dips that rely primarily on antimicrobial killing action.

ReVive is available as a concentrated liquid requiring dilution in tank water before use. The amber-colored solution has a distinctive scent reflecting its botanical origins. The product comes in various bottle sizes to accommodate different usage volumes, from hobbyist quantities suitable for occasional quarantine dipping to larger professional sizes for retail operations and coral farms processing many specimens. The concentrated formula provides economical treatment costs per coral, particularly when compared to the potential losses from untreated pest introductions.

Within the coral dip market, ReVive occupies a position as a gentle yet effective option particularly suited for routine quarantine applications and sensitive coral species. Many aquarists consider it their default dip choice for general pest prevention, reserving more aggressive treatments for confirmed infestations of specific pest organisms. The product's long market presence and association with Julian Sprung's expertise in coral husbandry lend it credibility that newer competing products must work to establish. This combination of proven effectiveness, gentle action, and expert endorsement has made ReVive a staple in responsible coral keeping.

Uses & Indications

The primary indication for ReVive Coral Cleaner is prophylactic treatment of newly acquired coral specimens before introduction to quarantine or display systems. Every coral purchased from retailers, received from fellow hobbyists, or collected from natural reefs carries potential hitchhikers that can establish problematic populations if introduced unchecked. These unwanted passengers range from visible pests like flatworms and nudibranchs to microscopic organisms and their eggs that escape visual detection. ReVive dipping provides a first-line defense against this constant introduction pressure, reducing pest populations before they gain foothold in closed aquarium systems.

Flatworm removal represents one of the most common specific applications for ReVive. Both Acropora-eating flatworms (AEFW) and the more common rust brown flatworms respond to ReVive treatment, releasing from coral tissue during the dip process. While dedicated flatworm treatments may provide more aggressive elimination for severe infestations, ReVive offers effective removal for light to moderate flatworm presence while simultaneously addressing other potential hitchhikers. Many aquarists employ ReVive as part of a multi-dip quarantine protocol, using it alongside more targeted treatments for specific confirmed pests.

Zoanthid and palythoa pest treatment has become an increasingly important application as these coral groups have grown in popularity. Zoanthid-eating nudibranchs, sundial snails, and various small predators specifically target these colonial polyps, often decimating collections before their presence is recognized. ReVive dipping helps remove these specialized predators along with their eggs, protecting valuable zoanthid colonies from the heartbreak of watching rare morphs disappear to hidden pests. The effectiveness against zoanthid-specific pests has made ReVive particularly popular among zoa collectors.

Support during coral acclimation and recovery from shipping stress represents a secondary benefit of ReVive treatment. The dipping process itself provides an opportunity for careful inspection of coral specimens, while the botanical components may provide some benefit to stressed tissues. Corals that have experienced extended shipping times, temperature fluctuations, or other stressors during transport often arrive with compromised mucus layers and reduced pest resistance. Early treatment removes opportunistic organisms that might otherwise take advantage of this vulnerable state.

Ongoing maintenance dipping for coral colonies showing signs of pest presence provides treatment utility beyond initial quarantine. When established tank corals display symptoms suggesting pest activity, such as tissue recession, unusual coloration, or visible organisms, removal and ReVive dipping can arrest developing infestations before they spread throughout the system. This therapeutic application requires careful handling to avoid compounding stress on already-affected specimens, but offers an intervention option between doing nothing and aggressive chemical treatments.

Dosage & Administration

Dosing ReVive Coral Cleaner follows manufacturer guidelines that recommend specific concentration ranges based on coral type and treatment goals. The standard protocol calls for mixing 40ml of ReVive concentrate per one gallon (approximately 3.8 liters) of clean saltwater from the source or destination aquarium. This concentration provides effective pest removal for most coral species while maintaining appropriate safety margins. Using tank water rather than freshly mixed saltwater ensures matching temperature, salinity, and chemistry, minimizing additional stress factors beyond the dip treatment itself.

Preparation of the dip solution requires a clean container of appropriate size for the specimens being treated. Glass or food-grade plastic containers work well, and many aquarists maintain dedicated dipping containers to prevent cross-contamination with other aquarium chemicals. The measured ReVive concentrate should be added to the appropriate water volume and mixed thoroughly before coral introduction. A characteristic slight turbidity and botanical scent confirm proper mixing. The solution should be prepared fresh for each dipping session, as standing solutions may lose effectiveness.

Exposure duration for standard prophylactic dips ranges from 5 to 10 minutes, with gentle periodic agitation throughout the treatment period. Agitation serves multiple purposes: it ensures solution contact with all coral surfaces including hidden crevices, it mechanically dislodges pests loosened by the treatment, and it provides oxygenation for the coral during the somewhat stressful dip process. Using a turkey baster, small powerhead, or manual swirling accomplishes this agitation effectively. Observation during the dip often reveals flatworms and other pests releasing from coral tissue, confirming the treatment's effectiveness.

For more aggressive treatment of confirmed pest infestations, extended dip durations up to 15 minutes may be employed, though this approaches the upper limit of coral tolerance for most species. Higher concentrations are not recommended and may cause tissue damage without proportionally increasing effectiveness. Instead, repeated dips spaced several days apart provide sustained pressure on pest populations while allowing coral recovery between treatments. A typical intensive protocol might involve three dips over ten days to address pests emerging from eggs laid before initial treatment.

Post-dip handling involves removing the coral from the dip solution and rinsing briefly in clean tank water before placement in the destination system. This rinse step removes residual ReVive and any dislodged pest organisms still clinging to the coral. A separate container with clean saltwater serves as an effective rinse station. Following the rinse, corals can be placed in quarantine or display tanks with normal acclimation considerations if parameters differ between systems.

Documentation of treatment parameters supports consistent and improving protocols over time. Recording the date, specimens treated, ReVive concentration, exposure time, and observed pest activity creates a valuable reference for future treatments. Noting any adverse reactions or particularly successful outcomes helps refine approaches for specific coral types. This systematic documentation transforms dipping from casual procedure into informed practice.

Side Effects

The most commonly observed side effect of ReVive treatment involves temporary polyp retraction and reduced extension during the hours following dipping. This stress response represents normal coral behavior when exposed to irritating stimuli and typically resolves within 24-48 hours as corals recover and resume normal activity. Most coral species tolerate this temporary disruption without lasting effects, particularly when water quality remains optimal during the recovery period. Reduced lighting intensity during the first day post-treatment may support faster recovery in sensitive specimens.

Mucus production often increases during and immediately following ReVive dips, representing the coral's natural response to irritation and pest removal. This mucus production is generally beneficial, as it helps expel dislodged pests and damaged tissue while providing protective coating for exposed surfaces. However, excessive mucus production in sensitive specimens may indicate treatment stress exceeding normal tolerance. If mucus production appears extreme or continues beyond the first few hours post-treatment, the coral should be monitored carefully for signs of tissue damage or infection.

Some coral species demonstrate heightened sensitivity to ReVive, showing more pronounced stress responses than typical specimens. Certain soft corals, particularly members of the Xenia and Anthelia genera, may display extended retraction periods lasting several days rather than hours. Goniopora species are noted for sensitivity to various dip treatments including ReVive. Very thin-tissued SPS corals, particularly some Montipora plating varieties and Seriatopora species, may show stress coloration or minor tissue damage from standard concentration treatments. Recognition of these sensitive species allows protocol modification to reduce adverse effects.

Direct tissue damage from properly conducted ReVive dips is uncommon but can occur under certain circumstances. Excessive concentration, extended exposure duration, or treatment of already-stressed specimens increases risk of tissue recession or bleaching. Temperature shock from significant differences between dip solution and source water compounds stress and may manifest as tissue damage attributed to the dip treatment. Avoiding these compounding factors through proper protocol adherence prevents most serious adverse effects.

Effects on symbiotic organisms living within or on coral specimens deserve consideration when evaluating treatment tradeoffs. Commensal crabs, shrimps, and small bristle stars that shelter among coral branches may be affected by ReVive exposure, potentially dying or abandoning their coral hosts. While generally considered acceptable collateral effects during pest removal, aquarists maintaining coral specimens valued specifically for their symbiont associations should weigh pest removal benefits against potential symbiont losses.

Contraindications

Severely stressed or actively declining coral specimens represent a primary contraindication for ReVive treatment. Corals experiencing tissue necrosis, significant bleaching, or active bacterial infections lack the physiological reserves to tolerate additional treatment stress. In such cases, stabilization through optimal water conditions, appropriate lighting, and freedom from additional stressors takes priority over pest removal. Once specimens show signs of recovery and stabilization, dip treatment becomes safer and more appropriate. Attempting to treat critically compromised corals often accelerates decline rather than promoting recovery.

Recently fragged coral fragments with extensive fresh wounds require cautious approach to dipping. While ReVive is generally gentler than iodine-based treatments on damaged tissue, the raw surfaces of fresh frag cuts lack normal protective barriers. Treatment of very fresh frags (less than 24 hours since cutting) may interfere with initial healing processes. Many coral farmers allow frags to recover for 1-3 days before subjecting them to dip treatments, permitting initial tissue sealing before introducing treatment chemicals. When immediate treatment is necessary, reduced exposure times provide some protection.

Certain highly sensitive species demonstrate poor tolerance for ReVive that effectively contraindicates standard treatment protocols. Goniopora species frequently appear on sensitivity lists across multiple dip products, and ReVive is no exception. Flowerpot corals often show significant stress responses to standard dipping, warranting either reduced concentration, shortened exposure, or consideration of alternative treatment approaches. Similarly, some delicate non-photosynthetic corals, including certain Tubastrea varieties, may respond poorly to dip treatments designed primarily for photosynthetic species.

The presence of valued symbiotic organisms creates situational contraindication based on keeper priorities rather than coral safety concerns. Specimens hosting prized commensal crabs, especially decorator crabs that may have taken considerable time to establish their displays, or rare symbiotic shrimp face loss of these inhabitants during dip treatment. When symbiont preservation takes priority over pest removal, mechanical inspection and manual removal of visible pests offers an alternative to chemical dipping, accepting reduced effectiveness against microscopic organisms and eggs in exchange for symbiont protection.

Drug Interactions

Sequential dipping with multiple coral treatment products requires appropriate spacing to prevent cumulative stress that exceeds coral tolerance. ReVive followed immediately by iodine-based dips, oxidizer treatments, or other coral cleaners compounds the physiological stress on treated specimens. When multiple treatments are indicated for different pest concerns, spacing dips by at least one week allows coral recovery between stressors. Some aquarists prefer alternating treatments across multiple weekly sessions rather than combining approaches in single treatment events, reducing peak stress while maintaining sustained pressure on pest populations.

Interactions with tank water chemistry during dip preparation warrant consideration for optimal treatment effectiveness. Water used for ReVive dips should be free of active chemical treatments, phosphate removers, or medications that might interfere with the botanical components. Using water from established tanks provides appropriate chemistry in most cases, but water from tanks recently treated with other medications may produce unpredictable interactions. When tank water is unavailable or unsuitable, freshly mixed saltwater matched to target tank parameters provides a neutral medium for dip preparation.

Copper-based medications represent the critical interaction concern that applies universally to invertebrate care, though the interaction is not specifically with ReVive but with the coral specimens themselves. Any copper contamination in dip containers, handling equipment, or water sources poses lethal risk to corals regardless of which dip product is employed. The copper warning bears constant repetition: trace contamination causes delayed mortality that may be incorrectly attributed to dip treatments. Dedicated coral-safe equipment that has never contacted copper medications is essential for all coral handling, not just ReVive dipping.

Activated carbon in dip containers would absorb botanical components and reduce treatment effectiveness, though this interaction would be an unusual error rather than common occurrence. More relevant is the role of carbon following dip treatment when corals return to systems with carbon filtration running normally. Some aquarists prefer removing carbon from quarantine systems during the period when newly dipped corals are recovering, reducing any chance of continued exposure to residual ReVive that might be released from coral mucus during the recovery period.

Precautions & Warnings

Proper concentration preparation requires attention to measurement accuracy and solution mixing. The specified 40ml per gallon represents the proven effective concentration; exceeding this amount does not improve effectiveness but increases stress on coral specimens. Conversely, under-concentration reduces pest removal effectiveness, potentially allowing hitchhikers to survive treatment and establish in destination systems. Using a graduated cylinder, measuring cup, or syringe ensures accurate dosing across treatments. Estimating concentrate amounts leads to inconsistent results and increases risk of both under- and over-treatment.

Temperature matching between dip solution and source water prevents thermal shock that compounds treatment stress. Coral specimens experience physiological stress from temperature changes, and combining thermal stress with chemical treatment stress may exceed tolerance thresholds. Preparing dip solutions from tank water automatically ensures temperature matching. When using freshly mixed saltwater, allowing the solution to equilibrate to room temperature or target tank temperature before use prevents cold shock. Temperature verification with an accurate thermometer before coral introduction catches potential problems before damage occurs.

Copper contamination awareness applies to all equipment used in coral handling and treatment. Containers, nets, turkey basters, and other tools previously used with copper medications retain trace contamination that proves lethal to invertebrates. Even thorough cleaning cannot guarantee complete copper removal from scratched or porous surfaces. The only safe practice involves maintaining dedicated coral-handling equipment that has never contacted copper, stored and labeled separately from fish medication supplies. This precaution is not specific to ReVive but applies universally to all coral handling situations.

Observation during treatment allows early detection of unusual stress responses that might warrant shortened exposure. While polyp retraction and mild mucus production are normal, extreme responses including severe mucus shedding, unusual color changes, or tissue appearance changes suggest individual coral sensitivity exceeding normal parameters. Having clean rinse water prepared before beginning the dip enables rapid removal if adverse responses develop. The few minutes invested in observation prevents the larger losses that result from unmonitored treatment of sensitive specimens.

Post-treatment monitoring continues for 24-48 hours following dipping, as some adverse effects manifest delayed rather than immediately. Checking treated corals periodically during the day following treatment identifies developing problems early while intervention remains possible. Documentation of both normal and unusual responses contributes to building understanding of species-specific sensitivities and refining protocols for future treatments.

Storage & Handling

Proper storage of ReVive Coral Cleaner maintains product effectiveness throughout its usable lifespan. The product should be stored in its original container with the cap tightly secured, in a cool location away from direct sunlight and temperature extremes. A cabinet or shelf in a climate-controlled room provides appropriate conditions. Unlike some products that require refrigeration, ReVive stores well at room temperature within normal household ranges. Extreme heat or freezing temperatures may affect the botanical components, potentially reducing effectiveness or changing solution properties.

Handling during use requires attention to measurement accuracy and cleanliness. The bottle should be shaken gently before dispensing to ensure uniform concentration throughout the liquid. Measuring the specified amount using a graduated cylinder, measuring cup, or large syringe provides consistent dosing across treatments. The bottle opening should remain clean and free of dried product residue that might interfere with pouring accuracy. If residue accumulates around the bottle opening, wiping with a clean cloth maintains ease of use.

Disposal of used dip solution and expired product should follow reasonable guidelines for household chemicals. Used dip solutions containing dislodged pests and coral mucus should not be poured back into aquarium systems, as they may contain pest eggs or organisms that survived treatment. Disposal down household drains is generally acceptable for the quantities involved in home aquarium use, though significant volumes from commercial operations might warrant more formal disposal approaches. Empty bottles can typically be recycled after rinsing, following local recycling guidelines for plastic containers.

Species Considerations

Among SPS coral species, Acropora demonstrates generally excellent tolerance for ReVive treatment at standard concentrations and exposure times. The firm tissue structure and robust mucus production typical of Acropora provides protection during treatment while allowing effective pest removal, particularly of the flatworms that commonly plague this genus. Montipora species similarly tolerate treatment well, though very thin-tissued plating varieties may benefit from slightly conservative exposure times. Pocillopora and Stylophora handle dipping without difficulty, making ReVive suitable for most common SPS varieties without special precautions.

LPS coral species present varied tolerance patterns requiring species-specific awareness. Most Euphyllia species (hammer, torch, frogspawn corals) tolerate ReVive treatment well despite their fleshy, extended polyp structure. The polyps typically retract during treatment and re-extend within 24-48 hours. Brain corals including Favia, Favites, and Goniastrea similarly handle treatment without unusual sensitivity. However, Goniopora and Alveopora species occupy the sensitive end of the spectrum, often showing extended stress responses to dip treatments. For these species, reduced exposure times of 3-5 minutes and careful observation help minimize adverse effects.

Soft corals and colonial polyps span a wide sensitivity range that defies simple generalization. Zoanthids, one of the primary target groups for ReVive treatment given their susceptibility to specialized predators, generally tolerate dipping well and represent an excellent application for the product. Leather corals (Sarcophyton, Sinularia) typically handle treatment with predictable polyp retraction and recovery. However, pulsing soft corals including Xenia and Anthelia often show heightened sensitivity, potentially requiring modified protocols. Mushroom corals fall in an intermediate range, tolerating treatment when healthy but potentially struggling when already stressed.

Anemones, while not corals, are often included in quarantine protocols and deserve consideration regarding ReVive tolerance. Most common anemone species, including bubble tip anemones and long tentacle anemones, tolerate brief ReVive exposure at conservative concentrations. However, the treatment duration should be reduced compared to coral protocols, typically 3-5 minutes rather than the full 10 minutes used for hardy corals. Careful observation during anemone dips is essential, as rapid closure may trap concentrated solution inside the animal's body cavity.

Related Medications

Several competing coral dip products occupy similar market positions to ReVive, offering alternative formulations for quarantine and pest removal applications. Coral Rx represents perhaps the most direct competitor, providing another established option for general-purpose coral dipping. Both products target similar pest organisms through similar mechanisms, and many aquarists have strong preferences for one or the other based on personal experience and results. Some keepers maintain both products, using each for different coral types or rotating between them across quarantine protocols. Comparative effectiveness studies remain limited, leaving product selection largely to individual preference and experience.

Iodine-based treatments including Lugol's Solution and Seachem Reef Dip provide alternative approaches emphasizing antimicrobial action rather than pure pest removal. These products excel at bacterial control and general disinfection, making them particularly valuable when tissue damage or bacterial infection concerns exist alongside pest hitchhiker worries. Some quarantine protocols incorporate both ReVive for pest removal and iodine dips for antimicrobial action, using them sequentially with appropriate spacing. The complementary mechanisms make this combination approach logical for comprehensive quarantine protection.

Dedicated pest-specific treatments target particular organism groups more aggressively than broad-spectrum dips like ReVive. Flatworm Exit (Salifert) specifically targets flatworms through mechanisms that prove more effective for heavy infestations than general dip products. Bayer Advanced Complete Insect Killer, used off-label by reef aquarists, provides aggressive action against crustacean pests including red bugs and certain parasitic copepods. These targeted products serve as second-line treatments when general dipping proves insufficient for specific pest problems, rather than replacements for the broad protection that products like ReVive provide in routine quarantine applications.