Lung Abscess in Reptiles

Quick Facts

🏥 Condition Name
Lung Abscess
📋 Also Known As
Lung Abscess
📂 Category
Respiratory System
📁 Subcategory
Lower Respiratory
🦎 Affects
Lungs and lower respiratory tract
🏷️ Type
Bacterial/Infectious
⚠️ Severity
Severe
💊 Treatable
Yes, often requires surgery
🔄 Contagious
No
🧬 Hereditary
No
🦎 Common In
Reptiles with chronic respiratory infections, immunocompromised reptiles

Lung Abscess Overview

Lung abscess is a serious complication of respiratory infection in reptiles, characterized by the formation of encapsulated pockets of infectious material within lung tissue. Unlike mammalian abscesses that contain liquid pus, reptile abscesses are filled with thick, caseous material with a consistency similar to cottage cheese or dry paste, a fundamental difference that has significant implications for treatment. This caseous nature means that reptile lung abscesses cannot be drained like mammalian abscesses and typically require surgical removal for resolution, making this condition one of the more challenging respiratory problems to treat in reptile medicine.

Lung abscesses can develop in any reptile species following respiratory infection, particularly when infections are chronic, inadequately treated, or occur in immunocompromised animals. The condition often develops as a complication of bacterial pneumonia that was not detected early or not treated aggressively enough. Abscesses may be single or multiple, and can range from small focal lesions to large masses occupying significant portions of the lung. The slow metabolism of reptiles means that abscesses often develop gradually over weeks to months, sometimes reaching substantial size before clinical signs become obvious enough to prompt veterinary evaluation.

The impact of lung abscesses on reptile health depends on their size, number, and location within the respiratory tract. Small, focal abscesses may cause minimal symptoms while gradually enlarging over time. Larger abscesses or multiple lesions significantly reduce functional lung capacity, leading to respiratory difficulty, reduced activity tolerance, and systemic effects from chronic infection. The chronic inflammatory state demands metabolic resources, often resulting in weight loss and muscle wasting. Additionally, bacteria within abscesses can periodically seed the bloodstream, potentially causing septicemia or infection of other organs.

Treatment of lung abscesses in reptiles requires a combination of surgical intervention and prolonged antibiotic therapy, guided by culture and sensitivity testing when possible. Medical therapy alone rarely resolves established abscesses because antibiotics cannot penetrate the caseous material effectively. Surgical removal of abscesses, while carrying inherent risks, offers the best chance of cure when lesions are accessible. Recovery from lung abscess surgery and the underlying infection requires extended time and excellent supportive care. Prevention through early detection and aggressive treatment of respiratory infections is far preferable to managing established abscesses.

Causes of Lung Abscess

The primary cause of lung abscesses in reptiles is bacterial infection that becomes localized and walled off by the immune system rather than being cleared. These abscesses typically develop as complications of bacterial pneumonia, particularly when infection is chronic, treatment is delayed or inadequate, or the reptile's immune system is compromised. Common bacterial species isolated from reptile lung abscesses include Pseudomonas, Aeromonas, Klebsiella, Proteus, and other gram-negative organisms prevalent in reptile environments. The bacteria that cause lung abscesses are often the same opportunistic pathogens responsible for other reptile infections, becoming problematic when conditions allow them to establish and persist in lung tissue.

Husbandry-related factors significantly contribute to lung abscess development by creating conditions that both promote infection and impair the immune response needed to clear it. Temperature inadequacy is paramount, as reptiles maintained too cold have suppressed immune function and cannot effectively fight respiratory infections before abscesses form. Chronic suboptimal temperatures allow infections to smolder rather than either resolving or causing acute illness, providing time for abscess development. Humidity extremes damage respiratory membranes and impair defense mechanisms. Poor ventilation and enclosure hygiene increase bacterial loads in the environment. These husbandry failures often underlie the chronic infections that eventually become walled off as abscesses.

Dietary factors and nutritional deficiencies predispose reptiles to both respiratory infections and poor abscess resolution. Vitamin A deficiency damages epithelial tissues including respiratory membranes, increasing susceptibility to infection and impairing healing. Calcium and vitamin D3 deficiency from inadequate UVB exposure or supplementation compromises overall health and immune function. General malnutrition from inappropriate diet weakens systemic immunity. Obesity may compromise respiratory function and reduce available lung capacity. Nutritional status directly influences the reptile's ability to fight infection before abscess formation occurs and to recover following treatment.

Environmental stressors contribute to immune suppression that allows localized infections to develop. Chronic stress from improper enclosure setup, aggressive tankmates, excessive handling, or inadequate hiding spots suppresses immune responses over time. Recent shipping or acquisition creates acute stress that may allow latent infections to progress. Overcrowding increases both stress and bacterial exposure. Wild-caught reptiles arrive stressed and often harboring subclinical infections that can progress to abscess formation in suboptimal captive conditions. Any factor that chronically compromises immunity increases the risk that respiratory infections will localize as abscesses rather than resolving.

The pathophysiology of lung abscess formation involves the reptile's immune response attempting to contain infection it cannot eliminate. When bacteria establish in lung tissue and the immune system cannot clear them through normal inflammatory processes, the body walls off the infection with fibrous capsule formation. Unlike mammals, where abscess contents liquefy and can potentially drain, reptile abscesses accumulate thick, caseous material composed of dead bacteria, immune cells, and cellular debris. This material cannot be reabsorbed or drained, instead accumulating over time as the abscess enlarges. The capsule surrounding the abscess prevents effective antibiotic penetration, protecting the bacteria within from therapeutic drug levels and allowing chronic infection to persist indefinitely without surgical intervention.

Symptoms & Warning Signs

Early warning signs of lung abscess development are often subtle because abscesses typically form gradually as complications of chronic respiratory infection. Owners may notice a failure to recover fully from what appeared to be a respiratory infection, with the reptile remaining slightly less active or having somewhat reduced appetite compared to normal baseline. Weight loss may continue despite apparent improvement in respiratory symptoms. Subtle changes in breathing pattern, particularly slight increase in effort or rate, may persist. The reptile may show marginally reduced exercise tolerance or become winded more easily than normal. These early indicators are frequently missed or attributed to slow recovery from the initial infection.

Common visible symptoms become more apparent as lung abscesses enlarge and compromise respiratory function. Respiratory effort increases, with visible movement of the body during breathing that becomes more pronounced over time. Some reptiles may breathe with mouths slightly open, particularly during activity or stress. Chronic weight loss occurs despite continued appetite, as the metabolic demands of ongoing infection exceed intake. Overall body condition deteriorates with visible muscle wasting along the spine and tail base. The reptile may show decreased activity and spend more time resting. Color may appear duller than normal.

Behavioral changes associated with lung abscesses reflect chronic illness and gradually worsening respiratory compromise. Activity level progressively decreases as the reptile conserves energy and compensates for reduced respiratory capacity. Basking behavior may intensify as the reptile seeks higher temperatures to support immune function, or may decrease as the reptile becomes too weak for effective thermoregulation. Appetite may slowly decline or become inconsistent as respiratory difficulty makes eating uncomfortable. The reptile may prefer elevated positions where breathing is easier or adopt unusual postures that facilitate respiration. Social interaction with owners diminishes as the reptile becomes increasingly lethargic.

Physical signs of lung abscesses detected during veterinary examination include reduced body condition, evidence of chronic illness, and respiratory abnormalities. Auscultation may reveal decreased or absent breath sounds in areas where abscesses occupy lung space, or may reveal abnormal sounds. The reptile may show visible respiratory effort during examination stress. Weight has typically declined from previous measurements, sometimes significantly. Dehydration may be present, indicated by reduced skin elasticity and slightly sunken eyes. In some cases, particularly in small reptiles, large abscesses may be palpable or cause visible asymmetry.

Symptom progression in reptiles with lung abscesses follows a gradual trajectory of worsening respiratory function if untreated. Respiratory difficulty slowly increases as abscesses enlarge and occupy more lung space. Body condition continues to deteriorate despite attempts to maintain nutrition. Some reptiles experience periods of acute worsening when bacteria from abscesses enter the bloodstream, causing episodes of severe illness interspersed with chronic decline. Eventually, respiratory compromise may become severe enough to cause obvious distress, inability to perform normal activities, and life-threatening hypoxia. Without treatment, the condition is ultimately fatal, though the timeline may extend over months to years depending on abscess growth rate and location.

Emergency symptoms requiring immediate veterinary intervention include sudden severe respiratory distress with pronounced open-mouth breathing and gasping, cyanosis evidenced by blue or purple discoloration of gums or tongue, collapse or inability to maintain normal posture, complete unresponsiveness, and signs of septicemia including extreme lethargy, color changes, and apparent shock. These emergency presentations may occur when abscess contents rupture into airways or bloodstream, causing acute crisis superimposed on chronic disease. Any sudden deterioration in a reptile with known or suspected lung abscesses requires emergency veterinary care.

Diagnosis

Physical examination by a reptile-experienced veterinarian provides initial assessment and raises suspicion for lung abscess based on clinical findings. Body condition is typically reduced, often significantly, with visible evidence of chronic illness including muscle wasting and weight loss. Respiratory pattern may show increased rate or effort, particularly when stressed. Auscultation may reveal decreased breath sounds in affected lung regions or may sound relatively normal if abscesses are small or focal. History typically reveals chronic or recurrent respiratory problems, often with partial response to treatment but failure to fully resolve. Recent respiratory infection with incomplete recovery is a common historical finding.

Diagnostic imaging is essential for identifying lung abscesses and differentiating them from other pulmonary pathology. Radiographs reveal discrete, well-defined densities within lung fields that appear as rounded or oval opacities with relatively sharp margins. Abscesses may be single or multiple and vary in size from small nodules to large masses. The radiographic appearance differs from diffuse pneumonia, which shows hazy increased density without focal masses. Computed tomography provides superior detail for assessing abscess size, number, and location, and is particularly valuable for surgical planning. CT imaging reveals the relationship of abscesses to surrounding structures and helps identify abscesses that might not be visible on standard radiographs.

Husbandry review is an essential component of diagnosis because environmental factors typically contribute to the chronic infections that lead to abscess formation. The veterinarian will inquire about temperature gradients, humidity, ventilation, and sanitation practices. History of prior respiratory infections and their treatment helps establish the timeline of disease development. Diet and supplementation practices are assessed for nutritional adequacy. Sources of stress are identified. Understanding husbandry allows identification of factors that contributed to disease and must be corrected for successful treatment and prevention of recurrence.

Additional diagnostic tests guide treatment decisions and help rule out other conditions. Fine needle aspiration of accessible abscesses provides material for cytology and culture, revealing the characteristic caseous material and identifying bacterial species. Culture and sensitivity testing determines appropriate antibiotic selection for post-surgical therapy. Complete blood count may show changes consistent with chronic infection, though reptile blood values require species-specific interpretation. Blood chemistry assesses organ function and overall health status. Cytology from tracheal wash may identify concurrent diffuse infection. In some cases, biopsy may be needed to differentiate abscesses from tumors or granulomas, particularly when imaging findings are ambiguous.

Treatment Options

Husbandry optimization is essential for treatment success and must accompany medical and surgical intervention. Environmental temperatures should be elevated to the upper end of the species-appropriate range to maximize immune function and support healing. Basking spots must reach optimal temperatures with reliable, monitored heating equipment. Humidity should be appropriate for the species, supporting respiratory health. The enclosure must be kept meticulously clean to reduce bacterial loads during recovery. Stress reduction through appropriate setup, hiding spots, and minimal handling supports the immune response. These environmental corrections are not optional additions to treatment but essential components required for recovery.

Surgical intervention is typically necessary for lung abscess resolution because medical therapy alone cannot eliminate established abscesses. The caseous nature of reptile abscesses means they cannot be drained like mammalian abscesses, requiring complete surgical removal. Surgery involves accessing the coelomic cavity, identifying the abscess, and carefully excising the entire encapsulated mass along with its fibrous wall. Multiple abscesses may require multiple surgical sites or staged procedures. In some cases, partial lung resection may be necessary when abscesses involve large portions of lung tissue. Surgery must be performed by veterinarians experienced with reptile surgical techniques and carries inherent risks including hemorrhage, air sacculitis, and anesthetic complications.

Medical management provides essential support before, during, and after surgical intervention. Preoperative stabilization addresses dehydration, nutritional deficiencies, and any acute complications. Antibiotic therapy based on culture and sensitivity testing from aspirated abscess material or tracheal wash begins before surgery and continues for extended periods afterward. Post-surgical antibiotics typically continue for four to eight weeks minimum to address residual bacteria and prevent recurrence. Supportive care including fluid therapy, nutritional support, and pain management assists recovery. Nebulization therapy may support respiratory health during the recovery period.

Supportive care addresses the systemic effects of chronic disease and the additional stress of surgery. Fluid therapy corrects and prevents dehydration, administered through routes appropriate for the species and situation. Nutritional support is essential, as affected reptiles often have depleted body reserves from chronic illness. High-quality, easily digestible foods should be offered, with supplemental feeding if necessary. Pain management is crucial for post-surgical comfort and recovery. Hospitalization may be necessary for intensive monitoring during the immediate post-operative period. Temperature support using supplemental heating helps maintain optimal body temperature during recovery.

Species-specific treatment considerations influence surgical approach and recovery management. Larger reptiles may be more suitable surgical candidates due to easier access and visualization of lung tissue. Aquatic species present challenges for post-surgical management, often requiring periods of dry-docking with carefully controlled access to water. Arboreal species may need modified enclosure setups during recovery to prevent falls or climbing-related complications. Species with particularly slow metabolism may require extended antibiotic courses and longer recovery periods. Small reptiles present surgical challenges due to tissue size and fragility. Individual factors including overall health status, age, and extent of disease influence surgical decisions more than species considerations in many cases.

Treatment timeline for lung abscesses in reptiles extends over months, requiring significant owner commitment. Surgical recovery takes two to four weeks for initial wound healing and return to basic function. Post-operative antibiotic therapy continues for six to twelve weeks in most cases. Complete recovery and return to normal body condition may take three to six months or longer. Follow-up imaging at intervals confirms resolution and monitors for recurrence. Owners must understand this extended timeline and the commitment required for successful treatment. Some reptiles may require additional surgery if new abscesses develop or if initial surgery was unable to remove all affected tissue.

Recovery & Prognosis

Recovery timeline for lung abscess surgery in reptiles requires patience, with complete healing measured in months. Initial surgical wound healing takes two to four weeks, during which the reptile requires careful monitoring and restricted activity. Return of appetite and activity typically occurs within one to three weeks post-surgery if recovery progresses normally. Complete resolution of infection and return to normal body condition may take three to six months, depending on the extent of disease and the reptile's overall health status. Some reptiles with extensive abscesses or concurrent health issues may require even longer recovery periods. Full recovery potential depends on how much functional lung tissue remains after abscess removal.

Post-treatment husbandry optimization supports healing and prevents recurrence. Environmental temperatures should remain optimized throughout recovery, with basking spots reaching appropriate temperatures. Humidity should be carefully controlled to support respiratory health without promoting bacterial growth. The enclosure should be kept exceptionally clean during recovery to minimize bacterial exposure while the reptile is immunocompromised. Substrate choices should minimize dust and potential irritants. Stress reduction through appropriate setup and minimal handling remains important. The husbandry deficiencies that contributed to original infection must be permanently corrected to prevent future problems.

Prognosis for lung abscesses depends on multiple factors including size and number of abscesses, success of surgical removal, overall health status, and correction of underlying causes. Reptiles with single, accessible abscesses that are completely removed surgically have good prognosis for recovery. Multiple abscesses or incomplete surgical removal carry higher risk of recurrence. Debilitated reptiles with poor body condition may struggle to recover even after successful surgery. Concurrent diseases that contributed to immune compromise must be addressed for full recovery. Continuation of husbandry problems that allowed initial infection predisposes to recurrence. Honest discussion with the veterinarian about individual prognosis helps owners make informed decisions.

Long-term monitoring and follow-up are essential components of recovery from lung abscess surgery. Radiographs should be repeated at intervals to confirm resolution and monitor for recurrence. Many veterinarians recommend imaging at two to four weeks post-surgery, again at eight to twelve weeks, and potentially at six months or one year. Body weight should be tracked to ensure continued improvement in condition. Owners should observe carefully for any return of respiratory symptoms that might indicate recurrence or new abscess formation. Even after apparent complete recovery, annual wellness examinations with imaging may be warranted to monitor for recurrence, particularly in the first few years after treatment.

Prevention

Proper husbandry setup is the most important factor in preventing lung abscesses by preventing the respiratory infections that lead to abscess formation. Temperature gradients must be species-appropriate, with basking spots reaching optimal temperatures and cool zones allowing behavioral thermoregulation. Digital thermometers with probes provide accurate temperature monitoring. Humidity should be maintained at appropriate levels for the species using hygrometers for monitoring. Ventilation should provide adequate air exchange without creating drafts. Enclosure cleanliness through regular cleaning and appropriate sanitation reduces environmental bacterial loads. These environmental factors directly influence respiratory health and infection susceptibility.

Dietary prevention supports immune function and overall health through species-appropriate nutrition. Complete, balanced diets provide necessary nutrients for immune competence. Calcium and vitamin D3 supplementation, or adequate UVB exposure, prevents deficiencies that compromise overall health. Vitamin A through appropriate food items or supplementation maintains epithelial tissue integrity. Hydration through species-appropriate water access supports respiratory membrane function. Avoiding nutritional deficiencies that impair immunity helps prevent the infections that can progress to abscess formation.

Early detection and aggressive treatment of respiratory infections prevents progression to abscess formation. Owners should observe breathing pattern daily and seek veterinary attention promptly for any signs of respiratory abnormality. When respiratory infections are diagnosed, treatment should be aggressive and continue for the full prescribed course. Follow-up veterinary visits confirm resolution before discontinuing treatment. Incomplete treatment or stopping antibiotics too early allows surviving bacteria to persist and potentially form abscesses. Taking respiratory infections seriously and treating them thoroughly is the key to preventing abscess complications.

Quarantine protocols protect established animals from respiratory infections that could progress to abscesses. New reptiles should be quarantined separately for minimum sixty to ninety days with careful observation for respiratory symptoms. Veterinary examination of new arrivals can identify subclinical infections before introduction to existing animals. Equipment used for quarantined animals should be kept separate and disinfected. Wild-caught reptiles and those from unknown sources warrant extended quarantine and more intensive screening. Preventing introduction of respiratory pathogens is far easier than treating established infections.

Veterinary relationships support prevention through professional health assessment and early intervention. Annual wellness examinations allow early detection of subclinical respiratory disease. Reptile-experienced veterinarians can assess husbandry and provide guidance for optimization. When respiratory symptoms occur, prompt veterinary care enables aggressive treatment before complications develop. Following prescribed treatment protocols completely, including full antibiotic courses and recommended follow-up visits, ensures infections are fully resolved. Understanding the serious consequences of inadequately treated respiratory infections motivates compliance with treatment recommendations.

Living With & Managing Lung Abscess

Ongoing husbandry requirements for reptiles recovering from lung abscess surgery or at risk for respiratory infections emphasize consistent optimal environmental conditions. Temperature monitoring should be continuous using reliable digital thermometers, with daily verification of appropriate gradients. Heating equipment should be inspected regularly and replaced proactively before failure. Humidity monitoring with hygrometers allows precise control at species-appropriate levels. Air quality benefits from adequate ventilation, appropriate substrates, and regular maintenance. For reptiles with history of respiratory disease, environmental conditions become especially critical and may warrant investment in backup heating systems and reliable monitoring equipment.

Environmental management and monitoring should become systematic daily practices following lung abscess treatment. Temperature and humidity checks at multiple times daily identify equipment malfunctions or environmental problems early. Enclosure cleaning follows enhanced schedules during recovery, with meticulous attention to sanitation. Substrates are selected to minimize dust and changed before becoming contaminated. Water sources remain clean and fresh. Equipment inspection and proactive replacement prevents failures. Documentation of environmental parameters and any health observations provides valuable records for veterinary follow-up.

Health indicator monitoring provides early warning of recurrence or new problems. Breathing should be observed multiple times daily, watching for any changes in rate, effort, or character. Weight tracking, ideally weekly, reveals trends that might indicate problems before they become clinically obvious. Appetite and food intake should be recorded. Activity level and behavior are noted and compared to post-recovery baseline. Any respiratory abnormality, weight loss, or behavioral change warrants prompt veterinary evaluation. Reptiles with history of lung abscesses face elevated risk of recurrence and require closer monitoring than animals without respiratory disease history.

Quality of life considerations guide ongoing care decisions for reptiles recovering from lung abscess surgery. Most reptiles that recover successfully from lung abscess surgery can achieve good quality of life with appropriate management. Those with significant lung tissue loss may have reduced exercise tolerance and require permanent environmental modifications. Signs of good quality of life include normal appetite, appropriate activity level, effective thermoregulation, and absence of respiratory distress. Reptiles that continue to struggle with respiratory symptoms despite optimal care, or those with recurrent abscesses, may have compromised quality of life requiring reassessment of care approach or difficult decisions about humane euthanasia.

Long-term care planning addresses the ongoing needs of reptiles with history of serious respiratory disease. Financial planning for potential veterinary costs, including possible recurrence requiring additional treatment, helps ensure continued access to care. Understanding that monitoring and potentially enhanced husbandry requirements may continue indefinitely sets appropriate expectations. Documentation of health history, surgical procedures, and medications provides essential information for ongoing care. Emergency planning includes knowing signs of respiratory crisis and locations of reptile-experienced emergency facilities. For long-lived species, succession planning ensures continued appropriate care throughout their lifespan.

Species at Risk for Lung Abscess

High-risk species for lung abscess development include reptiles commonly affected by respiratory infections and those frequently maintained in suboptimal conditions. Bearded dragons commonly develop respiratory infections that can progress to abscess formation, particularly when kept at inadequate temperatures or exposed to pathogens in overcrowded retail settings. Aquatic turtles face respiratory infection risk from poor water quality and temperature, with abscesses forming when infections become chronic. Tortoises, particularly those with chronic upper respiratory disease syndromes, may develop lower respiratory complications including abscesses. Any species can develop lung abscesses given appropriate conditions of chronic infection and immune compromise.

Captive versus wild-caught considerations influence lung abscess risk through effects on baseline health and stress. Wild-caught reptiles frequently arrive with subclinical respiratory infections that can progress to abscesses when combined with import stress and suboptimal captive conditions. Parasitic burdens common in wild-caught animals compromise immunity and may contribute to respiratory disease susceptibility. Long-term captive-bred reptiles from reputable sources generally have lower infection pressure and less immunocompromising history. However, captive-bred animals from high-volume operations may experience overcrowding and pathogen exposure that increases risk. Individual health history matters more than simple origin classification.

Species-specific susceptibilities relate to anatomy, common husbandry challenges, and respiratory infection patterns. Species with complex or sensitive respiratory systems may be more vulnerable to infection complications. Those commonly kept in inappropriate conditions have higher rates of chronic respiratory disease. Species requiring specific humidity levels may face respiratory challenges when these are not provided. Young reptiles may be more susceptible to severe infection complications. Geriatric animals may have declining immune function that allows infections to progress to abscess formation. Species commonly affected by immunosuppressive viral infections face increased risk of secondary bacterial complications including lung abscess formation.

Related Conditions

Commonly co-occurring conditions with lung abscesses typically include the respiratory infections that preceded abscess formation. Bacterial pneumonia often represents the initial infection that became localized and walled off. Upper respiratory infections may be concurrent or may have preceded lower respiratory involvement. Chronic systemic infections may be present, as the same immune compromise that allowed abscess formation may permit other infections. Nutritional deficiencies, particularly vitamin A deficiency, often underlie susceptibility to respiratory infections. Parasitic infections may contribute to immune suppression. Metabolic bone disease may indicate the husbandry problems that also predisposed to respiratory disease. Addressing all concurrent conditions is essential for successful treatment and prevention of recurrence.

Conditions with similar symptoms to lung abscesses require differentiation for appropriate treatment. Granulomatous pneumonia may appear similar radiographically, requiring cytology or biopsy for differentiation. Lung tumors can mimic abscess appearance on imaging. Diffuse bacterial pneumonia has different radiographic appearance but similar clinical signs. Fungal infections may present with focal masses resembling abscesses. Foreign body reactions can create localized masses. Thorough diagnostic workup including imaging, cytology, and culture differentiates these conditions and guides appropriate treatment.

Secondary complications of lung abscesses can significantly worsen prognosis. Septicemia occurs when bacteria from abscesses enter the bloodstream, potentially causing systemic infection and shock. Abscess rupture into airways can cause acute respiratory crisis. Chronic weight loss and muscle wasting from ongoing infection compromise overall health and recovery potential. Additional abscess formation may occur in remaining lung tissue or in other organs. Respiratory failure from progressive loss of functional lung tissue represents the ultimate complication if treatment fails. Post-surgical complications including hemorrhage, infection, and air sacculitis may affect recovery from surgical intervention.