The Amazon Milk Frog derives its common name from two sources: its origin in the Amazon rainforest basin, and the peculiar milky-white toxic secretion produced by skin glands when stressed or threatened. This white secretion resembles milk in appearance and inspired the "milk frog" designation. The secretion is a defensive mechanism discouraging predators through both physical irritation and visual warning. The Amazon origin specifies the geographic source, distinguishing them from other milk frogs or tree frogs. The combination creates a descriptive and memorable common name that is universally recognized in the amphibian hobby.
Alternate common names include "Mission Golden-Eyed Tree Frog," referencing their striking golden eyes with black cross-shaped pupils and historical associations with missions in South America where early naturalists encountered them. This romantic name is used occasionally though "Amazon Milk Frog" dominates popular usage. Other variations include "Blue Milk Frog" (emphasizing the blue-gray coloration that develops with age), "Panda Bear Tree Frog" (referencing the black and white banded pattern), and simply "Milk Frog" when context is clear. In South American countries within their range, various Portuguese and Spanish names exist including regional variations referencing their appearance or toxic secretion.
Scientifically, Amazon Milk Frogs belong to the genus Trachycephalus, family Hylidae (tree frogs), one of the largest and most diverse frog families. The genus Trachycephalus contains several large-bodied South American tree frogs. The genus name Trachycephalus is derived from Greek words meaning "rough head," referencing textured skin or cranial characteristics. The specific epithet "resinifictrix" is Latin meaning "resin maker," directly referencing the sticky, resinous secretions produced by the skin. These secretions serve both as defensive toxins and potentially as antibacterial or antifungal protection.
The species was scientifically described by Goeldi in 1907 based on specimens from Brazil. Taxonomic history includes various generic placements, with the species formerly placed in genus Phrynohyas before modern authorities recognized Trachycephalus as the appropriate genus based on phylogenetic relationships. No subspecies are currently recognized, though some geographic variation exists in coloration and size across the extensive Amazonian range. Northern populations may differ slightly from southern populations, though differences are not formalized taxonomically.
The distinctive appearance, impressive size, relative hardiness, and beautiful coloration have made Amazon Milk Frogs extremely popular in the amphibian hobby. They are among the most commonly kept large tree frogs and are widely captive-bred, with multiple generations of domestically produced animals available. This extensive captive breeding means most specimens in the pet trade are captive-bred rather than wild-caught, improving their health and reducing conservation impacts compared to species relying primarily on wild collection.

