The African Clawed Frog derives its common name from two key features: its origin in Africa, and the distinctive black claws on the three inner toes of each hind foot. These horny black claws are unique among frogs, inspiring the universally recognized common name. The claws are used for tearing apart food and potentially for defense or gripping, distinguishing Xenopus from typical webbed-footed frogs. The African origin specifies the continental source, differentiating them from other aquatic frogs. The combination of African origin and clawed feet creates a descriptive and memorable common name.
Alternate common names include "Platanna" (from Afrikaans, particularly used in South Africa), "Common Platanna," and simply "Clawed Frog" when context is clear. In scientific and medical research contexts, they are often called "Xenopus" without further specification, as X. laevis is the primary species used in laboratory research. Historical literature occasionally uses "African Claw-Toed Frog" or variations. The species has been so extensively used in laboratory settings that "lab frog" is sometimes used colloquially, though this emphasizes research use rather than natural history.
Scientifically, African Clawed Frogs belong to the genus Xenopus, family Pipidae, which includes the clawed frogs and Surinam toads. The family Pipidae is unique among frogs for being entirely aquatic throughout their lives. The genus Xenopus contains approximately 20-30 species (exact number debated due to taxonomic complexity) distributed across sub-Saharan Africa. The genus name Xenopus is derived from Greek words meaning "strange foot," directly referencing the distinctive clawed feet that characterize the genus. The specific epithet "laevis" is Latin meaning "smooth," referring to the relatively smooth skin compared to wartier frog species.
The species was scientifically described by Daudin in 1802, relatively early in amphibian taxonomy. For much of the 20th century, African Clawed Frogs gained fame for an unusual application: pregnancy testing in humans. Before modern immunological tests, female frogs were injected with women's urine, and if the woman was pregnant, hormones in the urine would cause the frogs to ovulate within 12-24 hours. This "Xenopus test" was widely used from the 1940s through 1960s, establishing extensive captive colonies and international distribution. This legacy explains why African Clawed Frogs became so widely available in research settings and eventually the pet trade. No subspecies are currently recognized, though geographic variation exists across their African range.

