The Giant Day Gecko has appeared in numerous nature documentaries focusing on Madagascar's extraordinary wildlife. Productions highlighting the island's endemic species frequently feature Phelsuma grandis because of its photogenic appearance and active daytime behavior, which makes it far easier to film than many nocturnal gecko species. These documentary appearances have helped establish the Giant Day Gecko as a visual shorthand for Madagascar's biodiversity in the public imagination.
Television programs dedicated to reptile keeping and exotic pets have regularly featured the Giant Day Gecko as a recommended species for intermediate hobbyists. Hosts and expert guests have showcased terrarium setups, feeding routines, and breeding techniques on camera, helping demystify reptile care for a broad audience. These segments often emphasize the gecko's vivid coloration and engaging personality, qualities that translate well to the screen and help challenge common misconceptions about reptiles as dull or unapproachable pets.
While the Giant Day Gecko has not starred in a major Hollywood production in the way some other reptile species have, its distinctive appearance has made it a popular choice for brief cameo roles in films and television shows that require an exotic or tropical animal. Set designers and animal coordinators value the species for its bright green color and calm demeanor under studio lighting, making it a practical choice for on-screen work.
Animated productions and children's programming have occasionally drawn inspiration from day geckos when designing reptile characters. The species' rounded features, large eyes, and bright coloration lend themselves well to character design, and several animated gecko characters bear a recognizable resemblance to Phelsuma grandis even when not explicitly identified as such.